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Menopause weight gain? You’re not stuck with it
The Prolon 5-Day Fasting Mimicking Diet (FMD) is the only nutrition program clinically proven to trigger autophagy, supporting fat-focused weight loss and protecting lean muscle, with food and science.
As featured in The Wall Street Journal, Vogue, Fortune, The Economist and The New York Times
Explore what’s possible
- Clinically proven average weight loss of 5.7 lbs per cycles
- Reduces waist circumference and BMI
- Targets fat loss while protecting muscle mass
+ Free Welcome Kit with subscription · HSA/FSA eligible
“Do three to four cycles, spaced through the year, to stay consistent and see the best results over time”
40+
Clinical trials
conducted with world-leading institutions
20k+
Physicians
Recommending Prolon to their patients
130+
Issued patents
for optimizing longevity and healthspan
$48M
In scientific research
confronting the four major causes of mortality
Clinical research conducted with
Research conducted with USC Leonard Davis School of Gerontology, Yale University School of Medicine, Harvard T.H. Chan School of Public Health, Mayo Clinic, Stanford University and Universitatsklinikum Heidelberg
18
Research institutions
25+
years of research
Prolon® 5-Day Fasting Mimicking Diet
Starting at $215.00 $182.75
The only nutrition program proven to trigger cellular renewal. A complete reset in five days.
Your order includes
- Prolon 5-Day kit: soups, nut bars, snacks and herbal teas
- Free Welcome Kit ($45 value) with your first subscription delivery: reusable water bottle, Fasting Shake, 3 Fasting Bars and L-Protein®
- Coaching support: dietitian guidance in the coach-led group
- Subscribe & Save 15%, pause, skip, cancel anytime
Choose your flavor:
Original, Bold and Expanded Variety are powdered. Just mix with water, perfect for on the go. Next Gen is ready to eat, no prep needed.
Original
From $182.75
Bold Flavors
From $182.75
Expanded Variety
From $191.25
Next Gen
From $216.75
Ready-to-eat organic soups (premium). The same science-backed fasting benefits, now in 100% organic, pre-cooked soups for enhanced taste, ease, and convenience. No mixing required.
Choose your offer:
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Best Value Save $38.25 (15% off)$255.00
$216.75
- Free shipping over $199
- Free Welcome Kit ($45 value)
- Flexible, pause, skip, cancel anytime
Delivery frequency
Buy 2 Boxes
Save $51.00 (10% off)$459.00
One-time purchase
$255.00
+ Free Welcome Kit with subscription · HSA/FSA eligible
One cycle is five days. Most customers run three to four cycles per year.
Published clinical study · over 120 days
Are you just losing weight, or losing the right kind of weight?
Prolon 5-Day FMD
Lost the fat. Kept the muscle.
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Matched the Mediterranean diet’s cardiometabolic benefits
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Protected more muscle than the Mediterranean diet in the study
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5.7 lbs lost and 1.6 inches off the waist across 3 cycles
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Five days at a time, not months of restriction
Mediterranean diet
Lost weight. Maintained muscle.
- ✕ Considered the gold standard for cardiometabolic health
- ✕ Delivered cardiometabolic benefits
- ✕ Helps maintain muscle mass
- ✕ Months of dietary change required
Rated 4.4 stars by 1M+ users
People can’t stop talking about it
Women in perimenopause and menopause keep sharing the same five days. Here is what they said after finishing the box.
In their own words
Reviewed on Trustpilot
Every review below was left by a verified customer on Trustpilot.
Individual results vary. These are individual customer experiences with the Prolon 5-Day program, published on Trustpilot, and are not guaranteed outcomes.
Why it works
7 reasons the weight comes off, and stays off
When paired with balanced eating and a healthy lifestyle between cycles.
What you lose matters more than how much you lose
In our daily life, cellular debris builds up — a root cause of premature aging and metabolic decline. Autophagy is our innate process of cellular cleanup. It is a biological miracle that revitalizes your body from the inside out. It’s so significant for human health that its discovery earned a Nobel Prize in medicine. Activating this process is the ultimate deep clean, a game-changer for your health, weight, immune function, and resilience.
The weight you lose is the weight you wanted to lose.
Five days at a time, not months of dieting
Most weight-loss approaches ask for forever: daily counting, weekly weigh-ins, restriction that drags on. The Prolon protocol runs five days at a time, then you go back to eating the way you normally eat.
While users lose an average of 5 lbs per cycle, published clinical trials show a weight loss of 5.7 lbs and waist reduction of 1.6 inches over three cycles. Five days a few times a year beats five months, every day.
You can eat while you lose
In our daily life, cellular debris builds up — a root cause of premature aging and metabolic decline. Autophagy is our innate process of cellular cleanup. It is a biological miracle that revitalizes your body from the inside out. It’s so significant for human health that its discovery earned a Nobel Prize in medicine. Activating this process is the ultimate deep clean, a game-changer for your health, weight, immune function, and resilience.
Precision nutrition, not deprivation.
The cellular work that makes the loss stick
By day three, your cells enter autophagy: damaged cellular components clear out, making way for healthier, younger functioning cells. Prolon is the only nutrition program clinically proven to trigger autophagy in humans.
For weight loss, that means the body isn’t just dropping water and muscle. It’s resetting metabolism from the inside out.
Reduced biological age, on top of pounds lost
In our daily life, cellular debris builds up, a root cause of premature aging and metabolic decline. Autophagy is our innate process of cellular cleanup. It is a biological miracle that revitalizes your body from the inside out. It’s so significant for human health that its discovery earned a Nobel Prize in medicine. Activating this process is the ultimate deep clean, a game-changer for your health, weight, immune function, and resilience.
The compound effect: a feeling of being lighter and younger, at the same time.
Published clinical results · biological-age markers shifted younger
No drugs. No injections. No extreme diets.
If you’ve looked at GLP-1s, tried crash diets, or worked through a shelf of supplements, the message has always been the same: force your body into results. Prolon takes the opposite approach. It works with your body’s own biological renewal processes.
Five days a few times a year, no prescriptions, no side-effect list to memorize, no plateau roulette.
25 years of research from USC, not a wellness trend
In our daily life, cellular debris builds up, a root cause of premature aging and metabolic decline. Autophagy is our innate process of cellular cleanup. It is a biological miracle that revitalizes your body from the inside out. It’s so significant for human health that its discovery earned a Nobel Prize in medicine. Activating this process is the ultimate deep clean, a game-changer for your health, weight, immune function, and resilience.
It’s the only nutrition program patented to support longevity through cellular rejuvenation.
The mechanism behind the results
Experience the Nobel-Prize winning mechanism of autophagy
Your cells clear out damaged material to make room for fresh ones. That process is autophagy, and we're the only nutrition program proven to activate it while eatin
What happens during a cycle
Day 6 to 7
Autophagy may continue through Days 6 and 7, even as you return to normal eating.
Questions
What people ask before their first program
Published clinical results show 5.7 lbs lost and 1.6 inches off the waist across three cycles, and users lose an average of about 5 lbs per cycle. Individual results vary, and what stays off depends on how you eat between cycles.
You eat every day. Each day brings plant-based soups, nut bars, olives, kale crackers, and herbal teas, portioned so your body reads the five days as a fast while you are still eating real food. Most people notice hunger most on day two, and it settles from day three.
The program is designed to target fat while protecting the lean muscle that keeps your metabolism strong, so you are not left with the rebound that follows crash dieting. Paired with balanced eating and a healthy lifestyle between cycles, the loss is more likely to hold. Most customers run three to four cycles a year.
Prolon comes out of 25 years of research at USC and is recommended by more than 20,000 physicians. It is a nutrition program, not a drug or an injection. Talk with your healthcare provider before starting if you are pregnant or nursing, underweight, or managing a medical condition.
The program is HSA/FSA eligible, and you can pay with Sika Health at checkout. Subscriptions stay flexible: pause, skip, or cancel anytime.
Five days. Real change.
Lose the fat. Keep the muscle. Reset the body, from the inside out. The protocol that 20,000+ physicians trust.
Subscribe & Save 15% · HSA/FSA eligible · Free shipping on orders over $199
© Prolon · L-Nutra. Patented fasting mimicking technology developed with the USC Longevity Institute.
These statements have not been evaluated by the FDA. Not intended to diagnose, treat, cure, or prevent any disease. Individual results vary.
Prolon is a nutrition program, not a treatment for menopause or any medical condition. Talk to your healthcare provider about what’s right for you.
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